In the present work, the LES turbulent spray combustion simulation in Flame Spray Pyrolysis (FSP) burner was carried out by open source OpenFOAM based on the gradient-type structural Subgrid-scale (SGS) model and partially stirred reactor (PaSR) combustion model (NLESPaSR). Meanwhile, an efficient multi-dimensional PBMC method was for the first time applied to describe the spatiotemporally-resolved formation and growth of nanoparticles in the FSP. The results show that the FSP is a strong turbulent combustion process. The temperature presents a bimodal distribution under the support of the surrounding pilot flame, and the rates of the three dynamic events reach the maximum all at the first temperature peak (HAB=0.012 m). The size of the nanoparticles increases gradually with the particle transport and increasing residence time. The competition among the three dynamic events, as well as the particles transport in the flame affect the evolution of particles.